Our practice is widely considered to be the epicenter for research in shortening the time of radiotherapy for early stage breast cancer. Women have busy lives and an active life outside of medicine. We recognized this 24 years ago, and began our search for an alternative to the usual 6 ½ weeks of external beam whole-breast irradiation. From Phase 1 to Phase 2 to the international Phase 3 randomized trial that completed in April of 2013. We have been and will be the leaders. This represents a paradigm shift in medicine.